TOR signalling regulates mitotic commitment through stress-activated MAPK and Polo kinase in response to nutrient stress.
Identifieur interne : 001480 ( Main/Exploration ); précédent : 001479; suivant : 001481TOR signalling regulates mitotic commitment through stress-activated MAPK and Polo kinase in response to nutrient stress.
Auteurs : Janni Petersen [Royaume-Uni]Source :
- Biochemical Society transactions [ 1470-8752 ] ; 2009.
Descripteurs français
- KwdFr :
- Aliments (MeSH), Animaux (MeSH), Humains (MeSH), JNK Mitogen-Activated Protein Kinases (métabolisme), Mitose (MeSH), Protein kinases (métabolisme), Protein-Serine-Threonine Kinases (métabolisme), Protéines de Schizosaccharomyces pombe (métabolisme), Schizosaccharomyces (cytologie), Schizosaccharomyces (enzymologie).
- MESH :
- cytologie : Schizosaccharomyces.
- enzymologie : Schizosaccharomyces.
- métabolisme : JNK Mitogen-Activated Protein Kinases, Protein kinases, Protein-Serine-Threonine Kinases, Protéines de Schizosaccharomyces pombe.
- Aliments, Animaux, Humains, Mitose.
English descriptors
- KwdEn :
- Animals (MeSH), Food (MeSH), Humans (MeSH), JNK Mitogen-Activated Protein Kinases (metabolism), Mitosis (MeSH), Protein Kinases (metabolism), Protein-Serine-Threonine Kinases (metabolism), Schizosaccharomyces (cytology), Schizosaccharomyces (enzymology), Schizosaccharomyces pombe Proteins (metabolism).
- MESH :
- chemical , metabolism : JNK Mitogen-Activated Protein Kinases, Protein Kinases, Protein-Serine-Threonine Kinases, Schizosaccharomyces pombe Proteins.
- cytology : Schizosaccharomyces.
- enzymology : Schizosaccharomyces.
- Animals, Food, Humans, Mitosis.
Abstract
Cell growth and cell division are coupled to control cell size and this co-ordination is often modulated by the availability of nutrients. In many eukaryotes, TOR (target of rapamycin) signalling is involved in coupling nutrient sensing to cell growth and division controls. Nutrient stress inhibits TOR signalling to advance the timing of cell division and thus leads to continued cell division at reduced cell size. Most changes in the environment stimulate stress-activated MAPK (mitogen-activated protein kinase) signalling pathways. Several MAPKs also have a general role in the control of mitotic onset and cell division. In the present paper, I discuss the interplay between two major signalling pathways, the TOR and the stress MAPK signalling pathways, in controlling mitotic commitment, with the main focus being on fission yeast (Schizosaccharomyces pombe).
DOI: 10.1042/BST0370273
PubMed: 19143645
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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In many eukaryotes, TOR (target of rapamycin) signalling is involved in coupling nutrient sensing to cell growth and division controls. Nutrient stress inhibits TOR signalling to advance the timing of cell division and thus leads to continued cell division at reduced cell size. Most changes in the environment stimulate stress-activated MAPK (mitogen-activated protein kinase) signalling pathways. Several MAPKs also have a general role in the control of mitotic onset and cell division. In the present paper, I discuss the interplay between two major signalling pathways, the TOR and the stress MAPK signalling pathways, in controlling mitotic commitment, with the main focus being on fission yeast (Schizosaccharomyces pombe).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19143645</PMID><DateCompleted><Year>2009</Year><Month>02</Month><Day>11</Day></DateCompleted><DateRevised><Year>2012</Year><Month>06</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1470-8752</ISSN><JournalIssue CitedMedium="Internet"><Volume>37</Volume><Issue>Pt 1</Issue><PubDate><Year>2009</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Biochemical Society transactions</Title><ISOAbbreviation>Biochem Soc Trans</ISOAbbreviation></Journal><ArticleTitle>TOR signalling regulates mitotic commitment through stress-activated MAPK and Polo kinase in response to nutrient stress.</ArticleTitle><Pagination><MedlinePgn>273-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1042/BST0370273</ELocationID><Abstract><AbstractText>Cell growth and cell division are coupled to control cell size and this co-ordination is often modulated by the availability of nutrients. In many eukaryotes, TOR (target of rapamycin) signalling is involved in coupling nutrient sensing to cell growth and division controls. Nutrient stress inhibits TOR signalling to advance the timing of cell division and thus leads to continued cell division at reduced cell size. Most changes in the environment stimulate stress-activated MAPK (mitogen-activated protein kinase) signalling pathways. Several MAPKs also have a general role in the control of mitotic onset and cell division. 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